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Abstract #1267

Towards correlating tissue status with dynamic PRF-T1 measurements using a single reference dual flip angle technique

Henrik Odéen1, Sara L Johnson1, Allison H Payne1, and Dennis L Parker1
1Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

Simultaneous PRF/T1 measurements using a single reference variable flip angle method is used to investigate the utility of T1 as a complimentary measure to thermometry for treatment outcome in MR guided thermal interventions, such as focused ultrasound. Both temperature and thermal dose have been shown to be inaccurate indicators of treatment outcome, creating a potential need for alternative quantitative metrics. This can be of particular value in adipose tissues where PRF has very low sensitivity. It is shown that the slope of the T1 vs. temperature curve correlates with amount of delivered thermal dose.

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