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Abstract #1268

Analysis of neurodegeneration using diffusion and functional MRI in FTLD model marmoset

Mitsuki Rikitake1, Junichi Hata2, Fumiko Seki3, Shinsuke Ishigaki4, Kuniyuki Iwata-Endo4, Nobuyuki Iwade4, Takako Shirakawa1, Hirotaka James Okano2, Hideyuki Okano5, and Gen Sobue4
1Department of Redioligical Science, Human Health Science, Tokyo Metroplitan University, Tokyo, Japan, 2Jikei University Graduate School of Medicine, Tokyo, Japan, 3Central Institute for Experimental Animals, Kanagawa, Japan, 4Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 5RIKEN Center of Brain Science, Saitama, Japan

Symptom of FTLD is known brain atrophy and neurodegeneration predominantly in frontal and temporal lobes.However, the regularity of neurodegeneration and image analysis methods have not been established.The purpose of this study was to conduct multiparametric MRI to analyze the neurodegeneration caused by FTLD using structural MRI and fMRI.We used marmosets, which have a relatively similar brain structure to humans, as the experimental subjects.Statistical imaging analysis using diffusion MRI showed gray matter degeneration was observed, mainly in the caudate nucleus.The fMRI showed decreased brain activity in the frontal lobe and basal ganglia.

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