Abstract #1268

Analysis of neurodegeneration using diffusion and functional MRI in FTLD model marmoset

Mitsuki Rikitake¹, Junichi Hata², Fumiko Seki³, Shinsuke Ishigaki⁴, Kuniyuki Iwata-Endo⁴, Nobuyuki Iwade⁴, Takako Shirakawa¹, Hirotaka James Okano², Hideyuki Okano⁵, and Gen Sobue⁴

¹Department of Redioligical Science, Human Health Science,　Tokyo Metroplitan University, Tokyo, Japan, ²Jikei University Graduate School of Medicine, Tokyo, Japan, ³Central Institute for Experimental Animals, Kanagawa, Japan, ⁴Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁵RIKEN Center of Brain Science, Saitama, Japan

Symptom of FTLD is known brain atrophy and neurodegeneration predominantly in frontal and temporal lobes.However, the regularity of neurodegeneration and image analysis methods have not been established.The purpose of this study was to conduct multiparametric MRI to analyze the neurodegeneration caused by FTLD using structural MRI and fMRI.We used marmosets, which have a relatively similar brain structure to humans, as the experimental subjects.Statistical imaging analysis using diffusion MRI showed gray matter degeneration was observed, mainly in the caudate nucleus.The fMRI showed decreased brain activity in the frontal lobe and basal ganglia.

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