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Abstract #1269

The Use of the 3He/129Xe MRI Lung Morphometry for a Longitudinal Observation of the Emphysema Progression in AATD Patients

Elise Noelle Woodward1, Matthew S Fox1,2, Tingting Wu3, Hacene Serrai1, David G McCormack4, Grace Parraga3,4,5,6, and Alexei Ouriadov1,2,6
1Physics and Astronomy, Western University, London, ON, Canada, 2Lawson Health Research Centre, London, ON, Canada, 3Department of Medical Biophysics, Western University, London, ON, Canada, 4Department of Medicine, Respirology, Western University, London, ON, Canada, 5Robarts Research Institute, London, ON, Canada, 6School of Biomedical Engineering, Western University, London, ON, Canada

In this study, we demonstrated a possible solution to underestimation of the global mean that can mask the severity of emphysema progression. Four patients with Alpha-1 Anti-Trypsin Deficiency disorder (AATD) were measured in 2014 using hyperpolarized He to measure lung function, and again in 2018 to measure lung function. While it is evident looking at morphometry images that there is a significant reduction in pixels and therefore emphysema progression, it is not at first evident in morphometry estimates. By normalizing these morphometry estimates of ADC/Lm, we can better characterize emphysema progression in individuals with AATD

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