Abstract #1269

The Use of the 3He/129Xe MRI Lung Morphometry for a Longitudinal Observation of the Emphysema Progression in AATD Patients

Elise Noelle Woodward¹, Matthew S Fox^1,2, Tingting Wu³, Hacene Serrai¹, David G McCormack⁴, Grace Parraga^3,4,5,6, and Alexei Ouriadov^1,2,6

¹Physics and Astronomy, Western University, London, ON, Canada, ²Lawson Health Research Centre, London, ON, Canada, ³Department of Medical Biophysics, Western University, London, ON, Canada, ⁴Department of Medicine, Respirology, Western University, London, ON, Canada, ⁵Robarts Research Institute, London, ON, Canada, ⁶School of Biomedical Engineering, Western University, London, ON, Canada

In this study, we demonstrated a possible solution to underestimation of the global mean that can mask the severity of emphysema progression. Four patients with Alpha-1 Anti-Trypsin Deficiency disorder (AATD) were measured in 2014 using hyperpolarized He to measure lung function, and again in 2018 to measure lung function. While it is evident looking at morphometry images that there is a significant reduction in pixels and therefore emphysema progression, it is not at first evident in morphometry estimates. By normalizing these morphometry estimates of ADC/Lm, we can better characterize emphysema progression in individuals with AATD

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