Hyperpolarization greatly increases the sensitivity of MRI studies of 13C-labeled substances. To expand our ability to investigate in vivo metabolism with hyperpolarized MRI, we developed a metabolite-specific 2D EPI pulse sequence with custom flyback spatially-selective RF pulses for [1-13C]pyruvate and [1-13C]lactate at 4.7T. Spectral profiles for each metabolite obtained using a [13C]urea phantom showed good correspondence with simulated profiles. In vivo testing was performed by imaging the liver and kidney of a rat following the injection of hyperpolarized [1-13C]pyruvate. Both the temporal and spatial resolution of [1-13C]pyruvate and [1-13C]lactate images was higher with our metabolite-specific EPI sequence than with CSI.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords