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Abstract #1270

Metabolite-specific echo planar imaging of hyperpolarized 13C-pyruvate at 4.7T

Tyler Blazey1, Galen D Reed2, Joel R Garbow1, and Cornelius von Morze1
1Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States, 2GE Healthcare, Dallas, TX, United States

Hyperpolarization greatly increases the sensitivity of MRI studies of 13C-labeled substances. To expand our ability to investigate in vivo metabolism with hyperpolarized MRI, we developed a metabolite-specific 2D EPI pulse sequence with custom flyback spatially-selective RF pulses for [1-13C]pyruvate and [1-13C]lactate at 4.7T. Spectral profiles for each metabolite obtained using a [13C]urea phantom showed good correspondence with simulated profiles. In vivo testing was performed by imaging the liver and kidney of a rat following the injection of hyperpolarized [1-13C]pyruvate. Both the temporal and spatial resolution of [1-13C]pyruvate and [1-13C]lactate images was higher with our metabolite-specific EPI sequence than with CSI.

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