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Abstract #1271

Feasibility of model-based omega-3 fatty acid fraction mapping using multi-echo gradient-echo imaging at 3T

Dominik Weidlich1, Julius Honecker2, Claudine Seeliger2, Daniela Junker1, Marcus R. Makowski1, Hans Hauner2, Dimitrios C. Karampinos1, and Stefan Ruschke1
1Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, 2Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Freising, Germany

A non-invasive method allowing the probing of the relative ω-3 fatty acid content in adipose tissue has the potential to reveal unknown metabolic patterns in physiology and pathology. In the current study, a model-based triglyceride mapping scheme is extended to enable the differentiation between ω-3 and non-ω-3 fatty acids by exploiting additional knowledge about the chemical shift properties. This extended scheme is combined with a chemical shift encoding imaging sequence and evaluated in a phantom validation experiment against gas chromatography–mass spectrometry. Furthermore, feasibility is demonstrated in both in vitro and in vivo settings.

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