Abstract #1286

Influence of equipment changes on a longitudinal trial

Ken Sakaie¹, Janel Fedler², Jon Yankey², Kunio Nakamura¹, Josef Debbins³, Mark J. Lowe¹, Paola Raska¹, and Robert J. Fox¹

¹The Cleveland Clinic, Cleveland, OH, United States, ²University of Iowa, Iowa City, IA, United States, ³Barrow Neurological Institute, Phoenix, AZ, United States

There is an urgent need for imaging biomarkers to develop new therapies for progressive multiple sclerosis. Hardware upgrades can confound the outcomes of imaging in clinical trials of such therapies. We examine different analytic approaches to evaluating the impact of and correcting for the effects of hardware changes in a retrospective analysis of SPRINT-MS, a multi-center clinical trial. Brain parenchymal fraction (BPF), a measure of atrophy, and transverse diffusivity (TD), a measure of demyelination are examined.

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