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Abstract #1286

Influence of equipment changes on a longitudinal trial

Ken Sakaie1, Janel Fedler2, Jon Yankey2, Kunio Nakamura1, Josef Debbins3, Mark J. Lowe1, Paola Raska1, and Robert J. Fox1
1The Cleveland Clinic, Cleveland, OH, United States, 2University of Iowa, Iowa City, IA, United States, 3Barrow Neurological Institute, Phoenix, AZ, United States

There is an urgent need for imaging biomarkers to develop new therapies for progressive multiple sclerosis. Hardware upgrades can confound the outcomes of imaging in clinical trials of such therapies. We examine different analytic approaches to evaluating the impact of and correcting for the effects of hardware changes in a retrospective analysis of SPRINT-MS, a multi-center clinical trial. Brain parenchymal fraction (BPF), a measure of atrophy, and transverse diffusivity (TD), a measure of demyelination are examined.

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