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Abstract #1287

Rapid Whole-Brain Myelin Mapping via Selective Inversion Recovery and Compressed SENSE

Ping Wang1, Nicholas Sisco1, and Richard Dortch1
1Barrow Neurological Institute, Phoenix, AZ, United States

There is a significant need for specific biomarkers of myelin damage and repair. Quantitative magnetization transfer (qMT) using selective inversion recovery (SIR) is able to quantify the macromolecular-to-free proton pool size ratio (PSR), which has been shown to relate closely with myelin content and disability. For clinical applications, SIR is often hampered by long scan times. As a result, we employed compressed sensing and parallel imaging to significantly reduce scan times, with little effect on the precision and accuracy of PSR estimates in white matter.

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