Although patients with end-stage renal disease (ESRD) have shown disrupted connectivity within and between resting-state functional networks, the patterns of change in dynamic functional network connectivity (FNC) remain unclear. The present work is the first study to investigate the dynamic functional connectivity in patients with ESRD. Patients with ESRD showed state-specific FNC disruptions and altered dynamic FNC properties. Furthermore, the total number of transitions was related to cognitive performance in those patients. These findings provided new insights into the pathophysiological mechanism of their cognitive deficits.