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Abstract #1292

Hippocampal segmentation from 7T images showed reduced subfields volume in Sickle Cell Disease subjects

Tales Santini1, Minseok Koo1, Nadim Farhat1, Vinicius P. Campos2, Salem Alkhateeb1, Marcelo A. C. Vieira2, Meryl A Butters1, Caterina Rosano1, Howard J Aizenstein1, Joseph Mettenburg1, Enrico M. Novelli1, and Tamer S Ibrahim1
1University of Pittsburgh, Pittsburgh, PA, United States, 2University of Sao Paulo, Sao Carlos, Brazil

Sickle cell disease (SCD) is an inherited hemoglobinopathy that can cause organ dysfunction such as cerebral vasculopathy and neurological complications. We explored whether SCD may be also associated with abnormalities in hippocampal subregions. We analyzed 7T MRI images from individuals with SCD and matched controls. Individuals with SCD had a significantly smaller volume of the DG+CA2+CA3 hippocampal region. Other hippocampal subregions also showed a trend towards smaller volumes in the SCD group. Further studies are necessary to investigate the mechanisms that lead to structural changes in the hippocampus subfields and their relationship with cognitive performance in SCD.

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