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Abstract #1301

Correlating Concussion-Related Symptoms to the Personalized MRI Assessment of Brain Abnormalities in Children

Ethan Danielli1,2, David Stillo1,2, Rachelle Ho3,4, Carol DeMatteo3,5, Geoffrey B Hall4, Nicholas A Bock4, John F Connolly1,4,5,6, and Michael D Noseworthy1,2,5,7,8
1School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 2Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 3School of Rehabilitation Sciences, McMaster University, Hamilton, ON, Canada, 4Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada, 5ARiEAL Research Centre, McMaster University, Hamilton, ON, Canada, 6Department of Linguistics, McMaster University, Hamilton, ON, Canada, 7Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 8Department of Radiology, McMaster University, Hamilton, ON, Canada

Although concussion diagnosis is often subjective, DTI can effectively quantify brain white matter damage. In this study, demographic and DTI metrics were compared between 26 paediatric concussion subjects against 49 healthy age and sex matched controls. FA was significantly reduced in injured brain regions and correlated with younger age and worsened symptoms. RD was significantly increased in injured brain regions and correlated with younger age and the interaction between time to scan and PCSS score. Based on these results, age affects concussion severity in younger children resulting in worse symptoms and a greater number of abnormal brain regions.

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