Abstract #1301

Correlating Concussion-Related Symptoms to the Personalized MRI Assessment of Brain Abnormalities in Children

Ethan Danielli^1,2, David Stillo^1,2, Rachelle Ho^3,4, Carol DeMatteo^3,5, Geoffrey B Hall⁴, Nicholas A Bock⁴, John F Connolly^1,4,5,6, and Michael D Noseworthy^1,2,5,7,8

¹School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, ²Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³School of Rehabilitation Sciences, McMaster University, Hamilton, ON, Canada, ⁴Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada, ⁵ARiEAL Research Centre, McMaster University, Hamilton, ON, Canada, ⁶Department of Linguistics, McMaster University, Hamilton, ON, Canada, ⁷Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, ⁸Department of Radiology, McMaster University, Hamilton, ON, Canada

Although concussion diagnosis is often subjective, DTI can effectively quantify brain white matter damage. In this study, demographic and DTI metrics were compared between 26 paediatric concussion subjects against 49 healthy age and sex matched controls. FA was significantly reduced in injured brain regions and correlated with younger age and worsened symptoms. RD was significantly increased in injured brain regions and correlated with younger age and the interaction between time to scan and PCSS score. Based on these results, age affects concussion severity in younger children resulting in worse symptoms and a greater number of abnormal brain regions.

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