Abstract #1302

Cerebral perfusion network analysis to understand cognition in old age: a principal component analysis of ASL-MRI

Jodi Karlyn Watt^1,2,3, Stefan Pszczolkowski^1,2,3, Yue Xing^1,2,3, Christopher Tench^1,2,3, Dorothee Auer^1,2,3, and Alzheimer's Disease Neuroimaging Initiative⁴

¹Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom, ⁴Alzheimer's Disease Neuroimaging Initiative, Los Angeles, CA, United States

A functional biomarker of age-related cognitive decline is yet to be elucidated but would be desirable to better understand detrimental and protective processes in order to promote cognitive health for the elderly. Challenges arise from multiple sources of variance across individuals and within brain perfusion maps with an unknown link between local or network function and clinical tests of global cognition. Principal Component Analysis provides the opportunity to address some of these knowledge gaps, by defining this relationship and relating this to underlying anatomical regions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.