Abstract #1303

Altered structural connectivity and impairment of brain network-cognition relationship in obstructive sleep apnea (OSA)

Tasfiya Islam¹, Mengting Liu¹, Dae Lim Koo², Ryan Cabeen¹, Eunyeon Joo³, and Hosung Kim¹

¹USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, United States, ²Department of Neurology, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea, Republic of, ³3Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Korea, Republic of

Obstructive sleep apnea (OSA) possibly affects individuals cognitively. To identify potential neurocognitive drawbacks for these patients, diffusion MRI and T1 neuroimaging data were collected from 148 OSA and healthy subjects. Structural brain networks were constructed using diffusion MR images. Network topological characteristics and localized connectivity were performed on diffusion related network along with brain and behavior relationships. It was found that the OSA individuals generally had greater modularity network measure, and impaired connectivity in several regions in the frontal lobe. Also, some of the brain connections and behavior relationships that were established in healthy subjects were disrupted for OSA patients.

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