Abstract #1304

QSM detects early alterations of brain venous blood oxygenation in fetuses with complex congenital heart diseases

Cong Sun¹, Aocai Yang¹, Jiaguang Song², Minhui Ouyang³, Jinxia Zhu⁴, Lei Xue⁵, Hao Huang^3,6, and Gunagbin Wang¹

¹Radiology, Shandong Medical Imaging Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China, ²Ultrasound, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China, ³Radiology Research, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ⁴MR Collaboration, Healthcare Siemens Ltd., Beijing, China, ⁵MR Application, Siemens Healthineers Ltd., Jinan, China, ⁶Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

We investigated the early changes of brain oxygenic metabolism in fetuses with complex congenital heart disease (CHD) and in normal fetuses across gestational ages. Using quantitative susceptibility mapping (QSM), we measured the venous blood oxygen saturation (SvO2) in utero of 22 fetuses with complex CHD and 88 healthy pregnancy controls. The SvO2 in normal fetuses was found to have no age-related change. SvO2 values were significantly higher in the CHD fetuses (80.8%±4.6%) than in the gestational age-matched normal fetuses (75.7%±8.0%) (p=0.038); which is evidence of altered human fetal brain oxygenic metabolism during the early stages of brain development.

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