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Abstract #1305

Quantitative cerebral oxygenation mapping by MRI with whole brain coverage compared to PET

Jan Kufer1, Christine Preibisch1,2, Samira Epp1, Jens Goettler1,3, Kilian Weiss4, Mikkel Bo Hansen5, Claus Zimmer1, Kim Mouridsen5, Fahmeed Hyder3, and Stephan Kaczmarz1,3
1Department of Neuroradiology, School of Medicine, Technical University of Munich (TUM), Munich, Germany, 2Department of Neurology, School of Medicine, Technical University of Munich (TUM), Munich, Germany, 3Department of Radiology & Biomedical Imaging (MRRC), Yale University, New Haven, CT, United States, 4Philips Healthcare, Hamburg, Germany, 5Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

Clinical imaging of the oxygen extraction fraction (OEF) is highly promising to improve stratification of patients with various neurological diseases. Measurement of OEF by multiparametric quantitative blood oxygen level dependent (mqBOLD)-MRI could greatly increase clinical applicability compared to the current gold standard PET. Furthermore, oxygen extraction capacity (OEC) has recently emerged as another MRI-based biomarker of cerebral oxygenation. However, studies comparing both MRI techniques to PET reference data are still lacking. Here, we present data from an MRI study in young healthy volunteers, demonstrating good agreement of both, MRI-based OEF and OEC, with PET data from a similar subject group.

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