Clinical imaging of the oxygen extraction fraction (OEF) is highly promising to improve stratification of patients with various neurological diseases. Measurement of OEF by multiparametric quantitative blood oxygen level dependent (mqBOLD)-MRI could greatly increase clinical applicability compared to the current gold standard PET. Furthermore, oxygen extraction capacity (OEC) has recently emerged as another MRI-based biomarker of cerebral oxygenation. However, studies comparing both MRI techniques to PET reference data are still lacking. Here, we present data from an MRI study in young healthy volunteers, demonstrating good agreement of both, MRI-based OEF and OEC, with PET data from a similar subject group.
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