Abstract #1306

Carbogen-based Cerebrovascular Reserve Using BOLD-based fMRI of Human Brain : tissue, territorial and cortical specificity

Tzu-chen Yeh^1,2, Chou-ming Cheng³, and Chi-che Chou³

¹Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan, ²Institue of Brain Science, National Yang-Ming University, Taipei, Taiwan, ³Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan

Carbogen-based cerebrovascular reserve (CO₂-CVR), derived from 90 normal subjects, was constructed for data-based approaches or analysis. Tissue, territorial and cortical specificities of CO₂-CVR were evaluated by regions of interest (ROI) approaches. Global ratio of GM/WM CO2-CVR was about 1.57. Territorial and cortical specificities of CO₂-CVR demonstrated (1) limited CO₂-CVR in territories of posterior circulation which supported the pathophysiology of posterior reversible encephalopathy syndrome and (2) vital function in distal territories of anterior cerebral artery as verified by cortical parcellation with the highest of CO₂-CVR at ventral portion of Brodmann area 23 (co-localized with posterior cingulate cortices of default mode network).

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