Abstract #1315

Inversion-recovery prepared 3D oscillating gradient sequence (IR-OGprep-GRASE) improves time-dependency measurements in the human brain

Haotian Li¹, Yi-Cheng Hsu², Tao Zu¹, Zhiyong Zhao¹, Ruibin Liu¹, Yi Sun², Yi Zhang¹, and Dan Wu¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²MR Collaboration, Siemens Healthcare China, Shanghai, China

Oscillating gradient diffusion MRI enables diffusion measurement at short diffusion-time (t_d), but it is challenging on the clinical system. Here we proposed an inversion-recovery prepared 3D oscillating gradient (IR-OGprep-GRASE) sequence to improve t_d–dependency measurements in the human brain. The result indicated that in brain regions that are possibly contaminated by CSF signals, such as the hippocampus, t_d-dependent ADC changes were not evident with OGprep-GRASE but can be recovered by adding the IR module. With IR-OGprep-GRASE, we identified different t_d-dependent patterns between the gray and white matter, as well as between the head, body, and tail of hippocampus.

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