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Abstract #1315

Inversion-recovery prepared 3D oscillating gradient sequence (IR-OGprep-GRASE) improves time-dependency measurements in the human brain

Haotian Li1, Yi-Cheng Hsu2, Tao Zu1, Zhiyong Zhao1, Ruibin Liu1, Yi Sun2, Yi Zhang1, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2MR Collaboration, Siemens Healthcare China, Shanghai, China

Oscillating gradient diffusion MRI enables diffusion measurement at short diffusion-time (td), but it is challenging on the clinical system. Here we proposed an inversion-recovery prepared 3D oscillating gradient (IR-OGprep-GRASE) sequence to improve td–dependency measurements in the human brain. The result indicated that in brain regions that are possibly contaminated by CSF signals, such as the hippocampus, td-dependent ADC changes were not evident with OGprep-GRASE but can be recovered by adding the IR module. With IR-OGprep-GRASE, we identified different td-dependent patterns between the gray and white matter, as well as between the head, body, and tail of hippocampus.

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