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Abstract #1316

ACcelerated Echo-train shifted EPTI (ACE-EPTI) for fast distortion-blurring-free high-resolution diffusion imaging with minimal echo time

Zijing Dong1,2, Fuyixue Wang1,3, Lawrence L. Wald1,3, and Kawin Setsompop4,5
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 4Department of Radiology, Stanford University, Stanford, CA, United States, 5Department of Electrical Engineering, Stanford University, Stanford, CA, United States

ACcelerated Echo-train shifted EPTI (ACE-EPTI) is proposed for fast and high-fidelity dMRI and diffusion-relaxometry. Distortion- and blurring-free imaging at high resolution is achieved using the time-resolved imaging approach, which recovers sharp multi-contrast images at each echotime across a continuous readout window. A new spatiotemporal encoding is proposed for rapid acquisition, requiring only 3 shots for submillimeter imaging with the capability of self-navigated physiological phase correction. An echo-training shifting acquisition is also incorporated into ACE-EPTI to enable shortest possible TE, which provides 30-40% higher SNR-efficiency over single-shot EPI. High-quality diffusion images and diffusion-weighted quantitative maps acquired by ACE-EPTI are demonstrated in-vivo.

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