Abstract #1331

Distortion-free high-resolution diffusion weighted imaging of mouse brain using diffusion-prepared 3D VF-RARE

Qiang Liu^1,2, Yuanbo Yang^1,2, Xinyuan Zhang^1,2, Yingjie Mei^1,2,3, Qiqi Lu^1,2, Guoxi Xie⁴, and Yanqiu Feng^1,2

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, ³Philips Healthcare, Guangzhou, China, ⁴Department of Biomedical Engineering, School of Basic Sciences, Guangzhou Medical University, Guangzhou, China

The purpose of the present work was to achieve three-dimensional (3D) high spatial resolution diffusion weighted imaging (DWI) of mouse brain using diffusion-prepared 3D VF-RARE (DP 3D VF-RARE) sequence at 7 Tesla. To employ long echo trains while prospectively controlling signal variation during acquisition, variable flip angles (VF) were implemented in the refocusing pulse train. The results showed improved image quality with less distortion over 2D single-shot EPI and comparable signal-to-noise ratio (SNR). With the application of the presented sequence, undistorted diffusion-weighted mouse brain images were obtained with high spatial resolution and potential SNR efficiency.

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