Diffusion-weighted MAVRIC is a novel pulse sequence that can obtain quantitative diffusion values in regions with high susceptibility. The goal of this work is to compare the quantitative accuracy of DWI-MAVRIC with sequences currently available on clinical MR scanners, using a diffusion phantom and images acquired at different orientation and spatial offsets in the scanner. Overall, good linearity with diffusivity was observed, with a large positive ADC bias at low diffusivity in both axial and coronal DWI-MAVRIC noted. Right and left spatial offsets increased ADC errors that can be mitigated by gradient nonlinearity correction.
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