Compared with the standard imaging method, i.e. single-shot echo planar imaging for diffusion MRI, Multi-Shot EPI (MS-EPI) is featured with high spatial resolution, though suffering from longer scanning time and severer phase variations. This study proposed a novel method to reconstruct four-shot high-resolution DWIs from one-shot data for multiple b-values simultaneously, enabling the physiological feature transformation through different b-values. Trained on healthy volunteers, we succeeded in recovering the aliasing images which violates the Nyquist-Shannon theorem from one-shot DWI both on healthy people and tumor patients, showing great clinical generalization.
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