Abstract #1435

Associations of pretreatment MRI with pathologic assessment of immune infiltration and chemotherapy response in triple negative breast cancer

Anum S. Kazerouni¹, Laura C. Kennedy², Michael Hirano¹, Daniel S. Hippe¹, Bonny Chau¹, Debosmita Biswas¹, Wesley Surento¹, Shaveta Vinayak¹, Matthew Nyflot¹, Habib Rahbar¹, Suzanne Dintzis¹, and Savannah C. Partridge¹

¹University of Washington, Seattle, WA, United States, ²Vanderbilt University, Nashville, TN, United States

We investigated the relationship between immune infiltration and imaging metrics derived from breast MRI in patients with triple negative breast cancer (TNBC) treated with neoadjuvant chemotherapy (NAC). Thirty-six patients with localized TNBC were imaged with diffusion-weighted and dynamic contrast-enhanced MRI prior to initiation of NAC. Baseline tumor infiltrating lymphocytes (TILs) and functional tumor volume were found to significantly differ between patients who achieved pathological complete response (pCR) compared to non-pCR patients. Baseline ADC showed a weak negative correlation with TIL counts.

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