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Abstract #1436

Measuring the tumour IFP using MRE: a mechanical biomarker for the prediction of metastatic potential in women with invasive breast cancer

Patriek Jurrius1,2, Omar Darwish1,3,4, Belul Shifa2, Joanna Bell2, John Spence2, Daniel Fovargue1, Giacomo Annio3, Renee Miller1, Marian Troelstra1, Ashutosh Kothari2, Hisham Hamed2, Diana Stavrou2, Ali Sever2, Sultana Hasso2, Katerina Ntailiani2, Keshthra Satchithananda5, Sarah Willson2, Sarah Pinder1,2, Anne Rigg2, David Nordsletten1, Radhouene Neji1,4, Arnie Purushotham1,2, and Ralph Sinkus1,3
1King's College London, London, United Kingdom, 2Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, 3University Paris Diderot, Paris, France, 4Siemens Healthcare Ltd., Frimley, United Kingdom, 5King's College Hospital NHS Foundation Trust, London, United Kingdom

Breast cancer is the most prevalent cancer among women. Over the years the overall survival has increased, with metastatic dissemination being one the most important prognostic factors. Currently, the presence of lymph node involvement or distant metastasis is diagnosed on imaging and core biopsy results. Yet, no technique to predict a cancer’s metastatic potential a priori is available. By incorporating magnetic resonance elastography (MRE) in a patient’s routine MRI scan the tumour interstitial fluid pressure, a factor associated with metastatic propensity, can be non-invasively measured. Preliminary results indicate a correlation between MRE measured tumour pressure and the cancer’s metastatic potential.

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