Abstract #1456

Whole-Brain Steady-State CEST at 3T Using MR Multitasking

Pei Han^1,2, Karandeep Cheema^1,2, Hsu-Lei Lee¹, Zhengwei Zhou¹, Tianle Cao^1,2, Sen Ma¹, Nan Wang¹, Anthony G. Christodoulou^1,2, and Debiao Li^1,2

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, UCLA, Los Angeles, CA, United States

We propose a fast 3D steady-state CEST (ss-CEST) method at 3T using MR Multitasking. By exploiting the correlation among images throughout the spatial, time, and offset frequency dimensions, the low-rank tensor framework shows a possibility for at least 2x acceleration of ss- CEST. High-quality quantitative maps can be generated from ss-CEST images. The Z-spectrum acquisition with whole-brain coverage can be done within 5.5min.

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