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Abstract #1472

Robust Quantitative T1rho imaging

Huimin Zhang1, Baiyan Jiang1, Jian Hou1, Queenie Chan2, and Weitian Chen1
1Imaging and Interventional Radiology, The Chinese University of Hong Kong, Sha Tin, Hong Kong, 2Philips Healthcare, Hong Kong, Hong Kong

T1rho is a valuable biomarker to probe macromolecular components in tissue. However, conventional T1rho quantification techniques are susceptible to B1 RF and B0 field inhomogeneities, which cause failure of spin-lock and signal oscillation. Adiabatic pulses have been used before and after spin-lock for simultaneous B1 RF and B0 field inhomogeneities compensation and have achieved robust spin-lock, but it does not remove the effect of field inhomogeneities to the actual T1rho value. Therefore, robust T1rho quantification still remains a problem. In this work, we utilized AC-iTIP and combined it with a proposed correction method to address this problem.

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