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Abstract #1475

Reproducible high-resolution T1Ρ maps of the brain in under seven minutes using compressed sensing

Gabriele Bonanno1,2,3, Tom Hilbert4,5,6, Patrick Leibig7, and Tobias Kober4,5,6
1Advanced Clinical Imaging Technology,Siemens Healthcare AG, Bern, Switzerland, 2Translational Imaging Center, sitem-insel AG, Bern, Switzerland, 3Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 7Siemens Healthcare GmbH, Erlangen, Germany

Relaxometry in the rotating frame can give unique insights into low frequency biological processes, and therefore may be a valuable quantitative MRI method for clinical research of neurodegenerative diseases. However, T maps require long scan times for whole-brain coverage with high isotropic resolution. We present a T mapping method based on an accelerated spiral-phyllotaxis 3D Cartesian gradient echo scan with compressed sensing reconstruction that allows for <7-min acquisition time and provides maps directly at the scanner to facilitate a fast workflow for clinical applications. Our method also demonstrated excellent repeatability and reproducibility.

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