Relaxometry in the rotating frame can give unique insights into low frequency biological processes, and therefore may be a valuable quantitative MRI method for clinical research of neurodegenerative diseases. However, T1ρ maps require long scan times for whole-brain coverage with high isotropic resolution. We present a T1ρ mapping method based on an accelerated spiral-phyllotaxis 3D Cartesian gradient echo scan with compressed sensing reconstruction that allows for <7-min acquisition time and provides maps directly at the scanner to facilitate a fast workflow for clinical applications. Our method also demonstrated excellent repeatability and reproducibility.
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