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Abstract #1476

Correction of errors in estimates of T1Ρ at low spin-lock amplitudes in the presence of B0 and B1 inhomogeneities

Zhongliang Zu1, Fatemeh Adelnia1, Kevin Harkins1, Feng Wang1, and John Gore1
1Vanderbilt University Medical Center, Nashville, TN, United States

Spin-lock imaging at low locking amplitudes are sensitive to the effects of water diffusion in intrinsic gradients and may provide information on tissue microvasculature. However, although composite pulse preparations have been used to reduce artifacts due to B0 and B1 inhomogeneities, there are still residual errors. Here, we analyze the source of these errors and developed an approximate theoretical analysis to correct these errors. Simulations and experiments on a healthy human subject show that these errors are mainly due to B0 shifts, and can be reduced by this correction approach when the B0 shift is relatively small compared with w1.

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