Inhomogeneous magnetization transfer (ihMT) is predominantly associated with myelin imaging and shows promise in detection and monitoring myelin related disorders, including multiple sclerosis (MS). Extraction of quantitative parameters from ihMT data (qihMT) would ideally provide information independent of the ihMT sequence. We used Cramer Rao lower bound analysis to develop an optimized acquisition protocol for qihMT and simulations to test the fidelity of the protocol. Preliminary application to central nervous system samples showed differences in free pool longitudinal relaxation rate R1a, bound pool transverse relaxation time T2b, and dipolar relaxation time T1d between specimens from donors with and without MS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords