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Abstract #1478

Comprehensive T1Ρ Measurement of in vivo Lumbar Intervertebral Discs using a 3D Adiabatic T1Ρ Prepared UTE (UTE-Adiab-T1Ρ) Sequence

Zhao Wei1,2,3, Alecio F. Lombardi1, Zubiad Ibrahim1, Mohammadamin Cheraghi1, Koihi Masuda4, Jiang Du1, Eric Y. Chang1,5, Graeme M. Bydder1, Wenhui Yang2,3, and Ya-Jun Ma1
1Department of Radiology, UC San Diego, San Diego, CA, United States, 2Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China, 3University of Chinese Academy of Sciences, Beijing, China, 4Department of Orthopedic Surgery, UC San Diego, San Diego, CA, United States, 5Radiology Service, Veterans Affairs, San Diego Healthcare System, San Diego, CA, United States

To assess the feasibility of using a 3D ultrashort echo time sequence with adiabatic T preparation (UTE-Adiab-T) to map the T of entire lumbar intervertebral discs (IVDs), 17 human subjects’ lumbar spines were scanned. Correlations between T values of all of the components of the IVD and disc degeneration grades and subjects' ages were calculated. T differences between subjects with and without low back pain were also assessed. The study showed that the UTE-Adiab-T sequence can measure T values of the whole IVD. These may be useful for assessment of IVD degeneration.

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