Abstract #1478

Comprehensive T1Ρ Measurement of in vivo Lumbar Intervertebral Discs using a 3D Adiabatic T1Ρ Prepared UTE (UTE-Adiab-T1Ρ) Sequence

Zhao Wei^1,2,3, Alecio F. Lombardi¹, Zubiad Ibrahim¹, Mohammadamin Cheraghi¹, Koihi Masuda⁴, Jiang Du¹, Eric Y. Chang^1,5, Graeme M. Bydder¹, Wenhui Yang^2,3, and Ya-Jun Ma¹

¹Department of Radiology, UC San Diego, San Diego, CA, United States, ²Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China, ³University of Chinese Academy of Sciences, Beijing, China, ⁴Department of Orthopedic Surgery, UC San Diego, San Diego, CA, United States, ⁵Radiology Service, Veterans Affairs, San Diego Healthcare System, San Diego, CA, United States

To assess the feasibility of using a 3D ultrashort echo time sequence with adiabatic T_1ρ preparation (UTE-Adiab-T_1ρ) to map the T_1ρ of entire lumbar intervertebral discs (IVDs), 17 human subjects’ lumbar spines were scanned. Correlations between T_1ρ values of all of the components of the IVD and disc degeneration grades and subjects' ages were calculated. T_1ρ differences between subjects with and without low back pain were also assessed. The study showed that the UTE-Adiab-T_1ρ sequence can measure T_1ρ values of the whole IVD. These may be useful for assessment of IVD degeneration.

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