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Abstract #1490

Sensitivity-enhanced and Shading-reduced Chemical Exchange Saturation Transfer Imaging of the Abdomen using Parallel Transmission

Ruibin Liu1, Zihua Qian2, Zhe Wu3, Yi-Cheng Hsu4, Caixia Fu5, Yi Sun4, Dan Wu1, and Yi Zhang1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Radiology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China, 3Techna Institute, University Health Network, Toronto, ON, Canada, 4MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, 5MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

CEST imaging benefits from longer saturation duration and a higher saturation duty cycle. Dielectric shading effects occur when the RF wavelength approaches the object size. Here, we proposed a parallel-transmission-based CEST (pTx-CEST) sequence to extend the maximum saturation duration at 100% duty-cycle and mitigate shading effects. The maximum saturation duration in pTx-CEST was lengthened to 2170, 3150, and 4130ms compared to 1050ms in non-pTx-CEST at TR of 3s, 4s, and 5s, respectively, leading to a significant sensitivity enhancement. Besides, the optimal amplitude ratio and phase difference between RF channels, manifesting circular or elliptical polarization, help reduce the dielectric shading effects.

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