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Abstract #1492

Altered brain networks dynamics in first-episode drug-free schizophrenia

Wanfang You1, Lekai Luo1, Qian Li1, Yuxia Wang1, Qiyong Gong1, and Fei Li1
1Huaxi MR Research Centre (HMRRC), Department of Radiology, West China Hospital of Sichuan University, chengdu, China

We investigated disturbances in dynamic functional connectivity (dFC) in whole-brain networks and altered dynamic functional topology of the brain regarding eigenvector centrality in first-episode drug-free patients with schizophrenia. By using resting-state functional magnetic resonance imaging (rf-MRI) data, schizophrenia was mainly manifested as prolonged dwell time in a state characterized by sparsely connected FCs and increased temporal variability of nodal centrality in the visual network, which may help us better interpret the mechanisms underlying visual and auditory hallucination in schizophrenia.

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