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Abstract #1493

Investigation of Frontal Alpha Asymmetry EEG Neurofeedback in Major Depression Using Simultaneous fMRI

Vadim Zotev1, Aki Tsuchiyagaito1, and Jerzy Bodurka1,2
1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States

We report a controlled study of emotion self-regulation training in patients with major depressive disorder (MDD) using frontal alpha asymmetry (FAA) EEG neurofeedback (EEG-nf) with simultaneous fMRI. MDD patients learned to significantly upregulate the FAA using EEG-nf while inducing happy emotion. Temporal correlations between the FAA and BOLD activity were significantly enhanced during the EEG-nf for many brain regions involved in emotion regulation, including the left DLPFC and the amygdala. Behavioral responses showed stronger approach bias after the training. Our study provides the first independent-modality evidence that the FAA-based EEG-nf can engage and influence the emotional brain circuitry.

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