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Abstract #1495

Functional and structural brain network features in Borderline Personality Disorder

Giovanni Sighinolfi1, Stefania Evangelisti2, Micaela Mitolo3, Claudio Bianchini2, Laura Ludovica Gramegna2,3, David Neil Manners2, Caterina Tonon2,3, Raffaele Lodi2,3, Francesca D'Adda2, Luca Pellegrini2, Marco Menchetti2, Domenico Berardi2, and Claudia Testa1
1Dipartimento di Fisica e Astronomia, Università di Bologna, Bologna, Italy, 2Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy, 3IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

This study uses a graph-based approach to analyse the brain MRI data of early-stage Borderline Personality Disorder (BPD) patients. The topological properties of their Functional Connectivity and Structural Covariance weighted networks are explored. Compared to healthy controls, BPDs exhibit statistically significant alterations at global level, in terms of efficiency and modularity, and at local level, in centrality and efficiency, especially from the functional perspective. The nodal variations are mostly observed in the limbic system, in particular in those regions associated to emotion regulation. Such results may be anticipating structural alterations emerging in later stages of the disease.

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