Abstract #1496

Static and dynamic functional connectivity in medication-free patients with obsessive compulsive disorder

Jing Liu¹, Hailong Li¹, Lingxiao Cao¹, Xue Li², Suming Zhang¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, ²Sichuan University, Chengdu, China

In current study, we use static and dynamic functional connectivity (sFC/dFC) to examine the connectivity alternation of bed nucleus of the stria terminalis (BNST) in medication-free patients with obsessive-compulsive disorder (OCD) to clarify the neural underpinnings of OCD. We found that BNST demonstrated different connected regions in sFC and dFC, indicating that the combination between sFC and dFC can help to detect BNST network alternations in OCD in a more comprehensive way by considering both the static and time-varying aspects.

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