Parkinson’s disease (PD) is one of the most common neurodegenerative disorders characterized by progressive deterioration of motor function as well as a non-motor symptom complex. Resting-state fMRI (rs-fMRI) provides important insights on the pathophysiological mechanisms of PD. Here we used rs-fMRI to systematically investigate the cerebellar functional connectivity changes in de novo drug naïve PD patients compared with healthy controls, and the association between altered cerebellar connectivity and neuropsychological assessments. Our findings support that cerebellar connectivity changes while reflective of early symptoms of PD, also may suggest a possible compensatory mechanism prior to clinical presentation of non-motor features of the disease.
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