Freezing-of-gait (FOG) can be attributed to overloading across neural networks in an attempt to compensate for reduced motor functions. Resting-state fMRI studies in Parkinson’s disease (PD) patients with FOG have implicated dysfunctional connectivity between cortical and subcortical regions over mainly the frontoparietal network, default mode, and visual networks. Our results suggest that despite not observing many global or local network differences there was a clear shift in the topological organization from occipital to frontal regions in both the PD-FOG patients and PD patients without FOG. Specifically, the PD-FOG groups showing significantly reduced rich-club connectivity when compared to the other groups.
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