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Abstract #1500

Reorganization of functional network topology in Parkinson’s disease patients with and without freezing of gait.

Karthik R Sreenivasan1, Xiaowei Zhuang1, Zhengshi Yang1, Dietmar Cordes1, Aaron Ritter1, Jessica Caldwell1, Zoltan Mari1, and Virendra Mishra1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States

Freezing-of-gait (FOG) can be attributed to overloading across neural networks in an attempt to compensate for reduced motor functions. Resting-state fMRI studies in Parkinson’s disease (PD) patients with FOG have implicated dysfunctional connectivity between cortical and subcortical regions over mainly the frontoparietal network, default mode, and visual networks. Our results suggest that despite not observing many global or local network differences there was a clear shift in the topological organization from occipital to frontal regions in both the PD-FOG patients and PD patients without FOG. Specifically, the PD-FOG groups showing significantly reduced rich-club connectivity when compared to the other groups.

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