Abstract #1501

Altered Amplitude of Low Frequency Fluctuation in Language Eloquent Areas in Patients with Medically-refractory Temporal Lobe Epilepsy

Li Jiang^1,2, Stephanie Chen³, Lorenna Vidal⁴, Jiachen Zhuo^1,2, Rao Gullapalli^1,2, and Prashant Raghavan²

¹Center for Advanced Imaging Research, University of Maryland Baltimore, Baltimore, MD, United States, ²Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore, Baltimore, MD, United States, ³Department of Neurology, University of Maryland Baltimore, Baltimore, MD, United States, ⁴Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States

Temporal lobe epilepsy (TLE) is the most common type of epilepsy in adults. Language impairment can result from both continued seizures and surgical attempts to treat it. Thus, accurate preoperative assessment of language function is essential. Here we used resting-state fMRI to investigate the altered amplitude of low frequency fluctuation (ALFF) in language eloquent areas in medically-refractory TLE patients and its relationship with clinical language test measures. Our findings suggest that left TLE disrupts language function more than right TLE and that intrinsic spontaneous brain activity is altered even in the absence of detectable clinical language impairment.

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