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Abstract #1502

Volumetric and connectivity profile of regional thalamic abnormality in amyotrophic lateral sclerosis

Sicong Tu1, Marion Sourty2, Fernando Calamante1, Manojkumar Saranathan3, Ricarda Menke4, Kevin Talbot4, Matthew Kiernan1, and Martin Turner4
1The University of Sydney, Sydney, Australia, 2Université de Strasbourg, Strasbourg, France, 3University of Arizona, Tucson, AZ, United States, 4University of Oxford, Oxford, United Kingdom

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with widespread extra-motor cortical and subcortical abnormality. The current findings highlight significant regional volumetric and connectivity abnormality in the thalamus associated with clinical features and may be a promising marker of disease burden.

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