In this study, we used dynamic functional connectivity (dFC) to characterize time-varying connectivity abnormalities of the precuneus in 27 patients with neuromyelitis optica spectrum disorders (NMOSD) and test their correlation with cognitive impairment. Compared to controls, NMOSD patients showed reduced precuneus dFC with deep grey matter, temporal, occipital, frontal and cerebellar regions. Increased dFC within the precuneus, and between precuneus and thalamic, insular and temporal regions was also detected. In NMOSD, abnormally high dFC correlated with depression and cognitive deficits.
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