Abstract #1504

Altered Resting State Dynamic Functional Connectivity of the Precuneus Contributes to Cognition and Depression in Neuromyelitis Optica

Paola Valsasina¹, Laura Cacciaguerra^1,2,3, Damiano Mistri¹, Vittorio Martinelli², Massimo Filippi^1,2,3,4,5, and Maria A. Rocca^1,2,3

¹Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, ²Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, ³Vita-Salute San Raffaele University, Milan, Italy, ⁴Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, ⁵Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy

In this study, we used dynamic functional connectivity (dFC) to characterize time-varying connectivity abnormalities of the precuneus in 27 patients with neuromyelitis optica spectrum disorders (NMOSD) and test their correlation with cognitive impairment. Compared to controls, NMOSD patients showed reduced precuneus dFC with deep grey matter, temporal, occipital, frontal and cerebellar regions. Increased dFC within the precuneus, and between precuneus and thalamic, insular and temporal regions was also detected. In NMOSD, abnormally high dFC correlated with depression and cognitive deficits.

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