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Abstract #1505

Pathological changes in subcortex disrupt cortical synchronization and metastability affecting cognitive function in Parkinson’s disease

Cheng Zhou1 and Minming Zhang1
1Zhejiang University, Hangzhou, China

In this paper, we investigated spatiotemporal dynamics of the phase interactions among resting-state blood oxygen level-dependent signals of Parkinson’s disease patients (n = 159) and normal controls (n = 152). We demonstrated that diminished dopaminergic function and the pathological changes in thalamus related structures responsible for decreased cortical synchronization and metastability, further affect cognitive function in Parkinson’s disease.

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