In this study, whole brain amplitude of low-frequency fluctuation (ALFF) changes have been respectively investigated for patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) and healthy controls (HCs). Relative to HCs, significantly lower ALFF values have been separately found in the regions of right supramarginal gyrus, left precuneus and right supplementary motor area for SCD and MCI patients. Additionally, the ALFFs at these regions also showed strong correlations with multiple clinical scales. Therefore, ALFF might be considered an effective index in the early detection of SCD patients.
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