Abstract #1506

Aberrant spontaneous low-frequency brain activity in patients with subjective cognitive decline: A resting-state fMRI study

Yin Tang¹, Ling Zhang¹, Yi Zhu², Hongyuan Ding¹, Yaxin Gao², Long Qian³, Weiqiang Dou³, and Ming Qi¹

¹Radiology department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²Rehabilitation Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³MR Research China, GE Healthcare, Beijing, China

In this study, whole brain amplitude of low-frequency fluctuation (ALFF) changes have been respectively investigated for patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI) and healthy controls (HCs). Relative to HCs, significantly lower ALFF values have been separately found in the regions of right supramarginal gyrus, left precuneus and right supplementary motor area for SCD and MCI patients. Additionally, the ALFFs at these regions also showed strong correlations with multiple clinical scales. Therefore, ALFF might be considered an effective index in the early detection of SCD patients.

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