Abstract #1507

The changes of regional homogeneity and voxel-mirrored homotopic connectivity in Preschool Children with sensorineural hearing loss: a resting-state fMRI

Yi Yin¹, Houyu Zhao², Guiquan Shen¹, Mingming Huang¹, Xiaoxu Zhang¹, Yawen Liu¹, Lisha Nie³, and Hui Yu¹

¹Department of Imaging, Affiliated Hospital of Guizhou Medical University, Gui yang, China, ²Department of Otorhinolaryngology, Affiliated Hospital of Guizhou Medical University, Gui yang, China, ³GE Healthcare, MR Research, Beijing, China

Long-term hearing loss can lead to changes in brain structure and function in preschool children with sensorineural hearing loss(SNHL). we uses regional homogeneity(ReHo) and voxel mirror homology connectivity(VMHC) methods to evaluate the abnormal changes of functional activities in regional brain and interhemispheric functional connections in children after hearing deprivation during resting-state. The results of this study showed that the structure and function of auditory related brain regions were reorganized, and the interhemispheric information transfer was also changed, which would contribute to a better understanding the neuropathological mechanism of preschool deafness.

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