Despite the prevalence of AD in women and the recognized sex-dependent genetic factors and male/female differences in cognitive measures in AD, how sex is related to AD phenotypic variability remains unclear. We demonstrated a varying spatial extent and magnitude of sex differences in brain function in an AD cohort, suggesting the dynamic contribution of sex in disease progression. Opposite network topological changes were observed from cognitively normal to MCI, and more rapid progression occurred in women than men from MCI to AD. The occipital lobe contributed more in men but frontal lobe contributed more in women in disease progression.
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