Meeting Banner
Abstract #1509

Multi-scale sex difference of brain function in Alzheimer’s disease

Zhengshi Yang1,2, Cieri Filippo1, Xiaowei Zhuang1,2, Marwan Sabbagh1, Jefferson W. Kinney2, Jeffrey L. Cummings2, Dietmar Cordes1,2,3, and Jessica Z.K. Caldwell1
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Nevada Las Vegas, Las Vegas, NV, United States, 3University of Colorado Boulder, Boulder, CO, United States

Despite the prevalence of AD in women and the recognized sex-dependent genetic factors and male/female differences in cognitive measures in AD, how sex is related to AD phenotypic variability remains unclear. We demonstrated a varying spatial extent and magnitude of sex differences in brain function in an AD cohort, suggesting the dynamic contribution of sex in disease progression. Opposite network topological changes were observed from cognitively normal to MCI, and more rapid progression occurred in women than men from MCI to AD. The occipital lobe contributed more in men but frontal lobe contributed more in women in disease progression.

This abstract and the presentation materials are available to members only; a login is required.

Join Here