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Abstract #1514

Potential Benefit of Multiband Multiecho EPI for Resting-state Functional MRI in Alzheimer's disease on a compact 3T system: A Preliminary study

Daehun Kang1, Myung-Ho In1, Erin Gray1, Thomas K Foo2, Radhika Madhavan2, Nolan K Meyer1, Lydia J Bardwell Speltz1, Zaki Ahmed1, Jeffrey Gunter1, Brice Fernandez3, Joshua D Trzasko1, John Huston1, Matt A Bernstein1, and Yunhong Shu1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2GE Global Research, Niskayuna, NY, United States, 3GE Healthcare, Buc, France

Using a high-performance gradient system, multi-band multi-echo fMRI with high temporal and spatial resolutions was acquired. The multi-echo images can be combined based on the weighting of local T2*. The echo-combination improves both the signal intensity and temporal SNR, particularly in regions suffering from signal dropout due to iron deposition like the basal ganglia. Also, the echo-combined images were demonstrated to be superior to the single-echo images for studying functional connectivity due to increased BOLD contrast sensitivity. Multi-echo fMRI is particularly promising for studies of aging and dementia as iron deposition and brain atrophy confound analyses.

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