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Abstract #1515

Evaluation and interaction of disease dependent head motion, low frequency oscillations, and cerebral blood flow in Alzheimer’s Disease cohort

Mu-Lan Jen1, Laura B. Eisenmenger2, Sterling C. Johnson3,4, Veena A. Nair2, Vivek Prabhakaran2, and Kevin M. Johnson1,2
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, United States, 4Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, 53705, WI, United States

Recent studies have suggested reduced altered low-frequency oscillations (LFOs) and cerebral blood flow (CBF) in subjects with Alzheimer’s disease (AD). These measures may reflect reduced neural activity and altered waste clearance but are subject to confounding effects from patient motion. This study of a cohort of AD and controls investigates interaction of patient motion with LFO from BOLD and CBF from multi-delay arterial spin labeling. Results demonstrate significantly increased motion in subjects with AD and a correlation of motion estimates with BOLD LFO but not with CBF. These results suggest motion should be considered for studies in neurodegenerative subjects.

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