Abstract #1515

Evaluation and interaction of disease dependent head motion, low frequency oscillations, and cerebral blood flow in Alzheimer’s Disease cohort

Mu-Lan Jen¹, Laura B. Eisenmenger², Sterling C. Johnson^3,4, Veena A. Nair², Vivek Prabhakaran², and Kevin M. Johnson^1,2

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, United States, ⁴Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, 53705, WI, United States

Recent studies have suggested reduced altered low-frequency oscillations (LFOs) and cerebral blood flow (CBF) in subjects with Alzheimer’s disease (AD). These measures may reflect reduced neural activity and altered waste clearance but are subject to confounding effects from patient motion. This study of a cohort of AD and controls investigates interaction of patient motion with LFO from BOLD and CBF from multi-delay arterial spin labeling. Results demonstrate significantly increased motion in subjects with AD and a correlation of motion estimates with BOLD LFO but not with CBF. These results suggest motion should be considered for studies in neurodegenerative subjects.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.