The purpose of this study was to apply a previously developed multi-contrast, multi-echo sequence using spin- and gradient-echo (SAGE) for fMRI in the context of Alzheimer’s disease (AD). We acquired pilot SAGE-fMRI data with five echoes (2 gradient-echoes, 2 asymmetric spin-echoes, 1 spin-echo) using episodic memory encoding and retrieval tasks in healthy aging and cognitively impaired (mild cognitive impairment (MCI) or mild AD) cohorts. Group differences in task-related activation were evaluated across single echo and multi-echo combined dynamic SAGE signals. SAGE-fMRI contrasts showed promise for more robust distinction between HC and CI groups than single-echo fMRI in AD-relevant brain regions.
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