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Abstract #1516

Implementation of multi-contrast, multi-echo SAGE-fMRI in aging and Alzheimer’s disease

Elizabeth G. Keeling1,2, Maurizio Bergamino1, Lori Steffes1, Anna Burke3, and Ashley M. Stokes1
1Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2School of Life Sciences, Arizona State University, Tempe, AZ, United States, 3Division of Neurology, Barrow Neurological Institute, Phoenix, AZ, United States

The purpose of this study was to apply a previously developed multi-contrast, multi-echo sequence using spin- and gradient-echo (SAGE) for fMRI in the context of Alzheimer’s disease (AD). We acquired pilot SAGE-fMRI data with five echoes (2 gradient-echoes, 2 asymmetric spin-echoes, 1 spin-echo) using episodic memory encoding and retrieval tasks in healthy aging and cognitively impaired (mild cognitive impairment (MCI) or mild AD) cohorts. Group differences in task-related activation were evaluated across single echo and multi-echo combined dynamic SAGE signals. SAGE-fMRI contrasts showed promise for more robust distinction between HC and CI groups than single-echo fMRI in AD-relevant brain regions.

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