Autism spectrum disorders (ASD) are characterized by dysregulation of endogenous oxytocin (OXT) function. In this study, we employed complexity of resting state fMRI signal as a tool to examine: 1) brain function impairments in adult ASD, 2) the relationship between DNA methylation of OXT receptor gene and severity of cognitive impairment, and 3) the effects of intranasal OXT treatment (IN-OXT). ASD patients exhibited abnormally increased fMRI signal complexity in a number of brain function networks. The severity of these impairments were inversely related to DNA methylation levels. IN-OXT attenuated impairments in these networks. Thus, OXT has neuroprotective effects in ASD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords