In this study, dynamic causal modeling (DCM) was applied to resting state fMRI data of mesial temporal lobe epilepsy (mTLE) patients to determine the directional alternations in effective connectivity in large scale brain networks. We hypothesized that mTLE alters the functional connectivity in both temporal and extra-temporal functional brain networks. We further hypothesized that the altered connectivity is directional (The direction between two network nodes matters). The results showed significantly different effective connectivity in default mode, limbic and salience networks.
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