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Abstract #1527

Task-phase fMRI evidencing cognitive improvement post carotid angioplasty and stenting (CAS) – initial findings of a follow-up study

Betty Chinda1,2, Simon Liang3, William Siu4, George Medvedev5, and Xiaowei Song1,2
1Department of Biomedical Physiology & Kinesiology, Simon Fraser University, Burnaby, BC, Canada, 2Health Research and Innovation, Fraser Health Authority, Surrey, BC, Canada, 3Department of Medicine, University of British Columbia, Vancouver, BC, Canada, 4Department of Radiology, Royal Columbian Hospital, New Westminster, BC, Canada, 5Department of Neurology, Royal Columbian Hospital, New Westminster, BC, Canada

This longitudinal task-phase fMRI study aims to provide direct evidence of possible effects of Carotid angioplasty and stenting (CAS) on cognition. The initial phase enrolled patients with severe carotid stenosis (≥70% stenosis) who had MRI scans pre-CAS and two-month post-CAS. At each scan, patients completed two fMRI sessions while performing a working memory task. Improved cerebral perfusion to areas supplied by carotid arteries following CAS was correlated with improved cognitive function in working memory performance along with increased fMRI activations in the re-perfused vascular territory especially in frontal and temporal lobes and reduced in the contralateral hemisphere.

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