Abstract #1537

Exploring cyto-architecture of Brodmann areas with High-resolution 3D MR Fingerprinting

Joon Yul Yul Choi¹, Siyuan Hu², Ting-yu Su^1,2, Yingying Tang¹, Ken Sakaie³, Ingmar Blümcke^1,4, Imad Najm¹, Stephen Jones³, Mark Griswold⁵, Dan Ma², and Zhong Irene Wang¹

¹Epilepsy Center, Neurological Institue, Cleveland Clinic, Cleveland, OH, United States, ²Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ³Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Neuropathology, University of Erlangen, Erlangen, Germany, ⁵Radiology, Case Western Reserve University, Cleveland, OH, United States

We demonstrate in this study the sensitivity of multi-parametric magnetic resonance fingerprinting (MRF) results at 3T to differentiate cortical regions with different cyto- or myelo-architecture. The study investigated the quantitative T1 and T2 values in various Brodmann areas to verify the sensitivity of MRF in probing tissue properties of the human cortex. Additionally, the study explores the relationship between quantitative T1 and T2 values of gray and white matter in Brodmann areas.

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