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Abstract #1537

Exploring cyto-architecture of Brodmann areas with High-resolution 3D MR Fingerprinting

Joon Yul Yul Choi1, Siyuan Hu2, Ting-yu Su1,2, Yingying Tang1, Ken Sakaie3, Ingmar Bl├╝mcke1,4, Imad Najm1, Stephen Jones3, Mark Griswold5, Dan Ma2, and Zhong Irene Wang1
1Epilepsy Center, Neurological Institue, Cleveland Clinic, Cleveland, OH, United States, 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 3Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 4Neuropathology, University of Erlangen, Erlangen, Germany, 5Radiology, Case Western Reserve University, Cleveland, OH, United States

We demonstrate in this study the sensitivity of multi-parametric magnetic resonance fingerprinting (MRF) results at 3T to differentiate cortical regions with different cyto- or myelo-architecture. The study investigated the quantitative T1 and T2 values in various Brodmann areas to verify the sensitivity of MRF in probing tissue properties of the human cortex. Additionally, the study explores the relationship between quantitative T1 and T2 values of gray and white matter in Brodmann areas.

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