Abstract #1536

Differentiation of Peritumoral White Matter in Glioblastomas and Metastases using Magnetic Resonance Fingerprinting

Charit Tippareddy¹, Walter Zhao², Andrew Sloan^3,4, Jeffrey Sunshine⁵, Jill Barnholtz-Sloan⁶, Mark Griswold^2,5, Dan Ma^2,5, and Chaitra Badve⁵

¹Case Western Reserve University School of Medicine, Cleveland, OH, United States, ²Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ³Departments of Neurosurgery and Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁴Seidman Cancer Center and Case Comprehensive Cancer Center, Cleveland, OH, United States, ⁵Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁶Department of Population and Quantitative Health Sciences, University Hospitals Cleveland Medical Center, Cleveland, OH, United States

The utility of MR fingerprinting (MRF) in characterization of non-enhancing tumor (NET) region in brain tumors has not been demonstrated. Quantitative characterization of NET (aka peritumoral white matter) in glioblastomas (GBM) is essential to identify imaging surrogates for tumor infiltration and predict future recurrence. Here we demonstrate the utility of pre and post contrast MRF to characterize and compare the NET region surrounding GBMs and metastases (METS). We identify NET radiomic features that are unique to each tumor type as well as features that can differentiate near (within 1 cm) versus far (beyond 1 cm) NET regions within each group.

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